CBD: Engineered By Nature

The term CBD is basically a short version of cannabidiol.  Cannabidiol is a chemical compound which comes from the hemp plant and is only one of many beneficial compounds found in hemp known as cannabinoids. 

In 2003, the US government patented CBD for medical use and made the following claim:

“CBD is a method of treating diseases caused by oxidative stress, comprising administering a therapeutically effective amount of a cannabinoid that has substantially no binding to the NMDA receptor to a subject who has a disease caused by oxidative stress.”

 

Cannabidiol may have a great deal of potential for a wide variety of ailments and have been shown in clinical settings to alleviate symptoms associated with anxiety, inflammation, nausea, convulsions and certain cancers.

 

Cannabinoids are produced by all cannabis plants and are fit for human consumption.  These cannabinoids are known as phytocannabinoids because they are plant based.  The fascinating part is that all mammals naturally produce their own cannabinoids, known as endocannabinoids.  If you were breast fed as a child, that was likely the last time you consumed CBD.  Endocannabinoids are a type of signaling molecule, otherwise called neurotransmitters.  Their function is to tell your cells to adjust according to internal or environmental factors.

The Endocannabinoid System

The endocannabinoid system is complex and would be difficult to describe in a few words. However, the important take away is that the human endocannabinoid system (ECS) is responsible for managing balance (homeostasis) within the body and is responsible for repairing damaged cells. You can think of this system as the "power grid" which feeds power to all of the body's other systems. It affects and regulates bodily processes such as mood, immune response, metabolism, appetite and more.  This system has two critical components, the first are the endocannabinoid receptors, CB1 and CB2 which are found on the surface of cells located throughout the entire body. Think of these receptors as locks. The second component would be the endocannabinoids, the signaling molecules which interact with the receptors. Think of these molecules as the keys which fit into the locks to activate the system.

Our bodies produce our own endocannabinoids which interact with those cannabinoid receptors.  However, the levels of these endocannabinoids will fluctuate due to factors such as poor diet, lack of sleep, environmental polutants, medications, and stress. In order to bridge the gap, it is phytocannabinoids, such as CBD, which play the role of enhancing and supporting optimal functionality of the endocannabinoid system.  Once CBD or other cannabinoids are ingested, the cannabinoid receptors are activated.  Research suggests that supplementing the endocannabinoid system with non-psychoactive cannabinoids, it is possible to improve overall well-being.

An article written in 2006 and published by The National Institutes of Health states “In the past decade, the endocannabinoid system has been implicated in a growing number of physiological functions, both in the central and peripheral nervous systems and in peripheral organs… modulating the activity of the endocannabinoid system turned out to hold therapeutic promise in a wide range of disparate diseases and pathological conditions, ranging from mood and anxiety disorders, movement disorders such as Parkinson’s and Huntington’s disease, neuropathic pain, multiple sclerosis and spinal cord injury, to cancer, atherosclerosis, myocardial infarction, stroke, hypertension, glaucoma, obesity/metabolic syndrome, and osteoporosis, to name just a few…”  See the full article here:  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2241751/

There are hundreds of peer-reviewed studies which indicate that CBD possesses rich clinical potential. A 2009 review recapped CBD’s therapeutic capabilities:

  • Anti-epileptic

  • Anti-psychotic

  • Anxiolytic

  • Anti-ischemic

  • Anti-emetic

  • Antispasmodic

  • Anti-inflammatory

  • Anti-diabetic

  • Antibacterial

  • Anti-cancer

  • Neuroprotectant

  • Vasorelaxant

 

The Cannabis Plant

CBD is the second most abundant compound in cannabis, and it can be found in both the marijuana (psychoactive cannabis) and in hemp (non-psychoactive cannabis).  Most legal products on the market will be extracts from hemp.

 

There are two main varieties of the cannabis plant which are Cannabis Indica and Cannabis Sativa. The Indica variety isn’t as well suited for the production of food or industrial purposes but is excellent to produce medical marijuana.  The Sativa variety produces more fiber and therefore is a preferable choice for hemp cultivation.

 

It is important to note that hemp and marijuana are different, even though they are both cultivated from different varieties of Cannabis Sativa.  Marijuana is cultivated for high levels of the psychoactive compound THC which is the compound that causes a high.  Both strains of Indica and Sativa are used to produce marijuana.

The hemp plant has been used since the dawn of the agricultural revolution. Everything from fiber, food, fuel, energy, and an estimated 50,000 other products makes the hemp plant one of the most versatile plants in the world. CBD is the predominant compound within the hemp plant, while the presence of THC is almost nonexistent. This allows for CBD uses to be extracted from the hemp plant, and allows it to be deemed a nutritional supplement and legal in all 50 states so long as it is lab-tested to ensure purity. 

Hemp contains cannabinoids and only trace amounts of THC.  Hemp will not make you high. In order to be legally cultivated, hemp must contain less than 0.3% THC.  Industrial hemp is normally grown for its fiber to be used in textiles, building materials and other applications.  However, since industrial hemp only contains small amounts of cannabinoids and terpenes, it isn’t the best choice for the production of CBD oil.

 

You will find many CBD products that are produced from industrial hemp; however, the CBD oil in

Don Leonardo Organics is produced from a CBD-rich strain called phytocannabinoid rich hemp (PCR Hemp).  Our oils provide naturally occurring phytonutrients including CBD, CBDa, flavonoids, terpenoids and other cannabinoids from the plant.  While each of these compounds has its own unique benefits, they work to enhance the effects of the other compounds present which is known as the entourage effect. 

Types of CBD Products

Tinctures / Sublingual Drops

Tinctures are the most common usage of CBD on the market and they are taken by placing drops under the tongue and holding for 30 to 60 seconds before swallowing.  We recommend starting with the lowest dosage of .25 ml, twice daily for about a week before making adjustments.

It’s important to pay attention to your own body and how it responds to the product as everyone’s physiology is different. Some people find they notice a response in a few minutes, and others it takes slightly longer with consistent use. You may find you need to increase the frequency of your servings to suit your own unique needs, and the key is to increase in small increments of .25 ml until you reach the desired effect. We suggest keeping a journal to keep track of your dosages and to note how you are feeling.

 

Capsules / Softgels

Some find that CBD capsules or softgels are their preferred method for taking CBD since they are easy to use and offer a consistent serving of CBD.  Our 25 mg softgels can be taken once or twice a day (or as needed) with water.  Our softgels can be taken with or without food.

Topicals

CBD topicals are a great way to support skin health and are known to help with anti-aging, inflammation, psoriasis, acne, chronic pain and many more.  Our 500mg salves are made with nano technology which helps carry the CBD through the dermal layers in order to achieve maximum efficacy.  Our salves can be applied using a dime sized amount to the desired area as often as needed to achieve the desired results.

 

Gummies (Edibles)

CBD edibles such as gummies are another way of getting your daily intake of CBD.  Don Leonardo Organics 25mg gummies are made from all natural ingredients and they taste great too!  Our CBD gummies are a great way to carry your CBD on the go.

Physician Recommendation

Contact your healthcare practitioner or physician about the endocannabinoid system and Cannabidiol (CBD) to explore every alternative out there for your healthcare needs. These alternatives may even include CBD uses. You can find many government clinical trials and online-published medical journals that explore the possibility of CBD oil medical facts, which should let you get the answer to the common question: “What is CBD good for?”

Media Mentions & Research Studies

CNN- N—Dr. Sanjay Gupta: Why I changed my mind on weed  

"We have been terribly and systematically misled for nearly 70 years in the United States, and I apologize for my own role in that. […] Keep in mind that up until 1943, marijuana was part of the United States drug pharmacopeia. One of the conditions for which it was prescribed was neuropathic pain…"

"Most frightening to me is that someone dies in the United States every 19 minutes from a prescription drug overdose, mostly accidental. Every 19 minutes. It is a horrifying statistic. As much as I searched, I could not find a documented case of death from marijuana  overdose." 

https://www.cnn.com/2013/08/08/health/gupta-changed-mind-marijuana/index.html

CNS Neuroscience & Therapeutics—Cannabidiol: A Promising Drug for Neurodegenerative Disorders?

… CBD, which constitutes up to 40% of the Cannabis extract, may represent the most promising candidate for clinical utilization due to its remarkable lack of any cognitive and psychoactive actions, in addition to its excellent tolerability profile in humans. Because of its very low toxicity in humans, many trials have been performed to assess the clinical efficacy of CBD in different pathologies.     https://onlinelibrary.wiley.com/doi/full/10.1111/j.1755-5949.2008.00065.x

 

Additional Research on CBD

Cannabinoids suppress inflammatory and neuropathic pain by targeting a3 glycine receptors.

 

The Endocannabinoid System, Cannabinoids, and Pain

 

The endocannabinoid system and the treatment of mood and anxiety disorders.

 

New Study Shows Cannabinoids Improve Efficiency of Mitochondria and Remove Damaged Brain Cells

 

Non-psychotropic plant cannabinoids: New therapeutic opportunities from an ancient herb

Interesting Hemp Facts

1 - All schoolbooks were made from hemp or flax paper until the 1880s. (Jack Frazier. Hemp Paper Reconsidered. 1974.)

2 - It was legal to pay taxes with hemp in America from 1631 until the early 1800s. (LA Times. Aug. 12, 1981.)

3 - Refusing to grow hemp in America during the 17th and 18th centuries was against the law! You could be jailed in Virginia for refusing to grow hemp from 1763 to 1769 (G. M. Herdon. Hemp in Colonial Virginia).

4 - George Washington, Thomas Jefferson and other founding fathers grew hemp. (Washington and Jefferson Diaries. Jefferson smuggled hemp seeds from China to France, then to America.)

5 - Benjamin Franklin owned one of the first paper mills in America, and it processed hemp. Also, the War of 1812 was fought over hemp. Napoleon wanted to cut off Moscow's export to England. (Jack Herer. Emperor Wears No Clothes.)

6 - For thousands of years, 90% of all ships’ sails and rope were made from hemp. The word ‘canvas’ is Dutch for cannabis. (Webster’s New World Dictionary.)

7 - 80% of all textiles, fabrics, clothes, linen, drapes, bed sheets, etc., were made from hemp until the 1820s, with the introduction of the cotton gin.

8 - The first Bibles, maps, charts, Betsy Ross’ flag, the first drafts of the Declaration of Independence and the Constitution were all made from hemp. (U.S. Government Archives.)

9 - The first crop grown in many states was hemp. 1850 was a peak year for Kentucky producing 40,000 tons. Hemp was the largest cash crop until the 20th century. (State Archives.)

10 - Oldest known records of hemp farming go back 5000 years in China, although hemp industrialization probably goes back to ancient Egypt.

11 - Rembrandt’s, Van Gogh’s, Gainsborough’s, as well as most early canvas paintings, were principally painted on hemp linen.

12 - In 1916, the U.S. Government predicted that by the 1940s all paper would come from hemp and that no more trees need to be cut down. Government studies report that 1 acre of hemp equals 4.1 acres of trees. Plans were in the works to implement such programs. (U.S. Department of Agriculture Archives.)

13 - Quality paints and varnishes were made from hemp seed oil until 1937. 58,000 tons of hemp seeds were used in America for paint products in 1935. (Sherwin Williams Paint Co. testimony before the U.S. Congress against the 1937 Marijuana Tax Act.)

14 - Henry Ford's first Model-T was built to run on hemp gasoline and the car itself was constructed from hemp! On his large estate, Ford was photographed among his hemp fields. The car, ‘grown from the soil,’ had hemp plastic panels whose impact strength was 10 times stronger than steel. (Popular Mechanics, 1941.)A

Article Source: usobserver.com

Ecology Facts

 

Hemp growers can not hide marijuana plants in their fields. Marijuana is grown widely spaced to maximize leaves. Hemp is grown in tightly-spaced rows to maximize stalk and is usually harvested before it goes to seed.

 

Hemp can be made into fine quality paper. The long fibers in hemp allow such paper to be recycled several times more than wood-based paper.

 

Because of its low lignin content, hemp can be pulped using less chemicals than with wood. Its natural brightness can obviate the need to use chlorine bleach, which means no extremely toxic dioxin being dumped into streams. A kinder and gentler chemistry using hydrogen peroxide rather than chlorine dioxide is possible with hemp fibers.

 

Hemp grows well in a variety of climates and soil types. It is naturally resistant to most pests, precluding the need for pesticides. It grows tightly spaced, out-competing any weeds, so herbicides are not necessary. It also leaves a weed-free field for a following crop.

 

Hemp can displace cotton which is usually grown with massive amounts of chemicals harmful to people and the environment. 50% of all the world's pesticides are sprayed on cotton.

 

Hemp can displace wood fiber and save forests for watershed, wildlife habitat, recreation and oxygen production, carbon sequestration (reduces global warming), and other values.

 

Hemp can yield 3-8 dry tons of fiber per acre. This is four times what an average forest can yield.

 

 

CBD: Engineered By Nature

Research continues to discover the tremendous health benefits of CBD without the psychoactive effects from THC.  We believe that we are nearing the end of prohibition for one of natures’ greatest gifts: CBD. The demand will only continue to increase for access to CBD, in fact, the CBD industry is poised to be a 20 Billion Dollar industry by the year 2020.  It’s clear that the time has come for natural alternatives such as CBD, and we at Don Leonardo Organics are excited to see what the future holds.

 

 

 

 

 

 

 

 

 

FDA Disclaimer:

The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from healthcare practitioners. Please consult your healthcare professional about potential interactions or other possible complications before using any product. The Federal Food, Drug, and Cosmetic Act requires this notice.

 
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